Translationella studier av tiopuriner för - SweCRIS


Lars-Göran Mårtensson - Linköping University

Patients with thiopurine S-methyl transferase (TPMT) or nucleotide diphosphatase (NUDT15) deficiency may be at an increased risk of severe and life-threatening myelotoxicity if receiving conventional doses of Azathioprine (see CLINCIAL PHARMACOLOGY). Death associated with pancytopenia has been reported in patients with absent TPMT activity Once thiopurine therapy has been undertaken and an equilibrated drug level is achieved (usually three to six months), literature suggests that the measurement of thiopurine metabolites is warranted in the following situations: 1. Thiopurine Metabolites - 6-Mercaptopurine (Purinethol) and its imidazolyl derivative, Azathioprine (Imuran), are immunosuppressive drugs. 6-Mercaptopurine (6-MP) is indicated for remission induction and maintenance therapy of acute lymphoblastic leukemia (ALL). Thiopurine therapy is associated with postoperative intra-abdominal septic complications.

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The genetic variants TPMT*2 to *19 are associated with decreased TPMT activity (2), and  Pharmacogenetics during standardised initiation of thiopurine therapy in inflammatory bowel disease. Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig  The Role of Inosine-5'-Monophosphate Dehydrogenase in Thiopurine Metabolism in Patients With Inflammatory Bowel Disease. Research output: Contribution to  Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-based Drugs: Evidence Report/Technology  Request PDF | On Feb 1, 2014, S. Almer and others published P573 A combination of low-dose thiopurine and allopurinol (ThioComp) is long-term efficacious  Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis | Ulf Hindorf; Khatoon Jahed;  av M Lindqvist · Citerat av 4 — trifosfaterna kan inkorporeras i DNA och. Pharmacogenetic studies of thiopurines. – focus on thiopurine methyltransferase.

Journal of the American  Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus.

Klinisk Biokemi i Norden Nr 4, vol. 7, 1995

Ecto-5′-nucleotidase and thiopurine cellular circulation: association with cytotoxicitys⃞ Those observations suggested the possible existence of a “thiopurine  Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism Zimdahl, Anna  The role of inosine-5'-monophosphate dehydrogenase in thiopurine metabolism in patients with inflammatory bowel disease. Genotypning av Thiopurine methyltransferase, eller mätning av enzymatisk aktivitet av TPMT, rekommenderas i nuläget inte som generellt startprov inom svensk  Farmakogenetik och underhåll. 6MP.




Meaning of thiopurine. What does thiopurine mean? Information and translations of thiopurine in the most comprehensive dictionary definitions resource on the web.

J. Bailey1, M. Zaman1, C. Titman2,  Syfte. Vid mag-tarmmottagningen behandlas patienter med inflammatoriska tarmsjukdomar (IBD) och autoimmun hepatit. Många av dessa  The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine  In paper III two other thiopurine prodrugs, cisacetylvinylthiopurine and trans-acetylvinylthioguanine, are investigated with the same human glutathione  thiopurine S-methyltransferase. Proc Natl Acad Sci USA. 1995 Feb 14;. 92 (4): 949 - 53. (3) Mackay IM. Real-time PCR in the microbiology laboratory.
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The optimal plasma levels are known, but there  1 jan 2008 TDM of thiopurine therapy in IBD. Theoretically, measuring metabolite levels of thiopurines could improve individual efficacy and safety of this  Limitations. This test should only be performed for patients currently on thiopurine therapy. This therapy includes administration of azathioprine or mercaptopurine. 26 Feb 2019 Thiopurines (mercaptopurine and its prodrug azathioprine) are commonly used in the management of inflammatory bowel disease (IBD).

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2016-08-29 · thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monitoring of thioguanine nucleotide levels while on treatment, guiding a personalised approach to optimising thiopurine therapy. INTRODUCTION Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gut, TPMT3 : Thiopurine methyltransferase (TPMT) deficiency is a condition in which patients treated with standard doses of azathioprine (AZA, Imuran), 6-mercaptopurine (6-MP, Purinethol), or 6-thioguanine (6-TG, Thioguanine Tabloid) may develop life-threatening myelosuppression or severe hematopoietic toxicity. / No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease. In: Nucleosides, Nucleotides & Nucleic Acids .

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Tiopuriner vid IBD och AIH - Behandling - Alfresco

Thiopurine S-methyltransferase deficiency patients have a mutation in either one or both copies of the TPMT Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Low-activity phenotypes are correlated with several mutations in the TPMT gene.

Azathioprine -

Tio-purinmetyltransferas (TPMT) är ett cyto- Azathioprine (AZA), a thiopurine prodrug, is utilized in the treatment of inflammatory bowel disease (IBD), both in Crohn disease (CD) and in ulcerative colitis (UC). Background: Thiopurine drugs are used to induce and maintain remission in inflammatory bowel disease. The methyl thioinosine monophosphate (meTIMP)/6-thioguanine nucleotide (6-TGN) concentration ratio has been related to drug response and adverse reactions. Individuals who are either homozygous or heterozygous for thiopurine methyltransferase (TPMT) deficiency are at risk of developing life-threatening myelosuppression or severe hematopoietic toxicity when placed on standard doses of azathioprine (AZA, Imuran), 6-mercaptopurine (6-MP, Purinethol), or 6-thioguanine (6-TG, Thioguanine Tabloid). Thiopurine drugs—6-mercaptopurine (6-MP), 6-thioguanine, and azathioprine—are used in the treatment of leukemia, autoimmune disorders, and solid tumors, as well as in organ transplantations.

Methylated. 6MP metabolites.